Cumulatively, the results indicate that mannose supplementation may be an optional approach to the treatment of colitis and other diseases associated with intestinal barrier dysfunction.Ĭathepsins encompass a family of lysosomal proteases that mediate protein degradation and turnover. Mannose exerts a synergistic therapeutic effect with mesalamine on mouse colitis. We demonstrate that mannose treatment enhanced lysosomal integrity and limited the release of cathepsin B, preventing mitochondrial dysfunction and myosin light chain kinase (MLCK)-induced tight junction disruption in the context of intestinal epithelial damage. Mannose treatment attenuates intestinal barrier damage in two mouse colitis models, dextran sodium sulfate (DSS)-induced colitis and spontaneous colitis in IL-10 -deficient mice.
We show here that the circulating level of mannose is increased in patients with IBD and mice with experimental colitis. Mannose, a natural bioactive monosaccharide that is involved in metabolism and synthesis of glycoproteins, exhibits anti-inflammatory and anti-oxidative activities. Metabolite alteration has been associated with the pathogenesis of inflammatory bowel disease (IBD), including colitis.
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